Clonal evolution permits outgrowth of chemoresistant LMPP-like early progenitors in relapsed NPM1c AML
Single-cell RNA-seq · human · 20 samples
- What it is
- Single-cell RNA-seqGene activity measured in thousands of individual cells, so cell types can be told apart. Read from the summary: GEO's own type field only says 'expression profiling by sequencing', so confirm it in the paper.
- Organism
- Homo sapiens (human)
- Topic
- Acute myeloid leukemiaThis series is part of our curated briefing on it.
- Samples
- 20 samples: 20 samples, each with a distinct title — no replicated groupsGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE296381_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Single-cell studies usually ship their counts as 10x files (matrix.mtx, barcodes.tsv, features.tsv), an .h5 file, or an .rds / .h5ad object that Seurat or Scanpy can open. Look for those among the supplementary files.
Also filed as BioProject PRJNA1259024 and SRA study SRP583184. Searching any of these in the dataset finder brings you back here.
Any grouping that defines a comparison lives in the sample characteristics, which GEO records separately from the titles.
How we read this: Read from 20 sample titles: 20 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8969426 NPM1 patient 01, diagnosis sample
- GSM8969427 NPM1 patient 01, relapse sample
- GSM8969428 NPM1 patient 02, diagnosis sample
- GSM8969429 NPM1 patient 02, relapse sample
- GSM8969430 NPM1 patient 03, diagnosis sample
- GSM8969431 NPM1 patient 03, relapse sample
- GSM8969432 NPM1 patient 04, diagnosis sample
- GSM8969433 NPM1 patient 04, relapse sample
- GSM8969434 NPM1 patient 05, diagnosis sample
- GSM8969435 NPM1 patient 05, relapse sample
- GSM8969436 NPM1 patient 06, diagnosis sample
- GSM8969437 NPM1 patient 06, relapse sample
- GSM8969438 NPM1 patient 07, diagnosis sample
- GSM8969439 NPM1 patient 07, relapse sample
- GSM8969440 NPM1 patient 08, diagnosis sample
- GSM8969441 NPM1 patient 08, relapse sample
- GSM8969442 NPM1 patient 09, diagnosis sample
- GSM8969443 NPM1 patient 09, relapse sample
- GSM8969444 NPM1 patient 10, diagnosis sample
- GSM8969445 NPM1 patient 10, relapse sample
- GSE122515 Bonn Dataset 3 of meta-analysis on AML classification, RNAseq dataset 0 samples same disease briefing · shares aml
- GSE137851 The long non-coding RNA HOXB-AS3 regulates ribosomal RNA transcription in NPM1-mutated acute myeloid leukemia 387 samples same disease briefing
- GSE270185 Repurposing CD19-directed immunotherapies for pediatric t(8;21) acute myeloid leukemia 249 samples same disease briefing
- GSE303795 Halofuginone exerts broad-spectrum cytotoxic effects by regulating p-eIF2α-S100A8/A9-calcium signaling, inhibiting global protein synthesis, and reversing the resistance of idarubicin in acute myeloid leukemia 6 samples same disease briefing
- GSE137574 Kevetrin induces apoptosis in TP53 wild-type and mutant acute myeloid leukemia cells 24 samples same disease briefing
- GSE129437 Genome-wde mapping of BRD9 binding sites and gene expression changes upon BRD9 knockdown 6 samples same disease briefing
- GSE296649 Clonal evolution permits outgrowth of chemoresistant LMPP-like early progenitors in relapsed NPM1c AML [scRNA-Seq] 58 samples shares npm1c, aml, chemoresistant, progenitors, evolution, outgrowth, lmpp-like, relapsed
- GSE270894 Molecular Characterization of Chemoresistant Cell Populations Improves Risk Stratification and Therapy Response Prediction in Pediatric AML [pAML Patients scRNA-seq] 20 samples shares aml, chemoresistant
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.