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p75 Neurotrophin Receptor Shapes the Dynamics of Adult Hippocampal Neurogenesis in Alzheimer's Disease

GSE296390 Mus musculus (mouse) RNA-seq (gene expression) 12 samples Submitted 2026/04/01 Platform GPL30172
At a glance

RNA-seq (gene expression) · mouse · 12 samples

What it is
RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
Organism
Mus musculus (mouse)
Samples
12 samples: 3 × Hippocampal tissue, WT, biol vs 3 × Hippocampal tissue, 5xFAD, biol vs 3 × Hippocampal tissue, p75NTRko, biol vs 3 × Hippocampal tissue, 5xFAD/p75NTRko, biolGroups are read from the sample names, not from the paper. Check the list below.
Data you can get
A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Paper
p75 neurotrophin receptor shapes the dynamics of adult hippocampal neurogenesis in Alzheimer's diseaseAlzheimer's research & therapy · 2026
Summary (written by the submitters)
Background In the present study, we explore the intricate relationship between the adult hippocampal neurogenesis and the p75 pan-neurotrophin receptor (p75NTR), under physiological or neurodegenerative conditions, focusing on Alzheimer's Disease (AD). The hippocampal adult neurogenesis, the process of generating new neurons in the Dentate Gyrus (DG), is crucial for cognitive function and emotional resilience.
Read the full summary ↓
Dysregulation of this process is strongly implicated in AD, a neurodegenerative disorder characterized by cognitive decline and memory impairment. p75NTR, known for its diverse functions in neuronal survival, differentiation and synaptic plasticity, emerges as a key player in modulating adult neurogenesis. In addition, its significant role in the context of AD has recently been revealed, although the exact mechanism of action remains elusive. Methods This study aims to address the connective relation of adult hippocampal neurogenesis and AD by investigating the role of the p75NTR in mouse and human neural stem cells under physiological and AD conditions. Results We firstly evaluated the impact of p75NTR in in vivo adult hippocampal neurogenesis, by performing 5-bromo-2′-deoxyuridine (BrdU) injections for detection of proliferation and immunohistochemistry analysis for key neurogenic markers in p75NTR knock-out (ko) mice, compared to the wildtype of 2-, 4-, and 6- months old mice, revealing the necessity of p75NTR, and defining its cell non-autonomous function to control neural stem cell fate. In order to investigate the role of p75NTR in AD, we have generated a mouse model by crossing the p75NTR ko mice with the 5xFAD mouse, an amyloid beta dependent mouse model of AD. Our data clearly indicate the importance of p75NTR expression for the proliferation and differentiation processes of adult neural stem cells (NSCs). Differential gene expression analysis confirmed the aforementioned properties. Finally, we investigate the p75NTR effects in human induced Pluripotent Stem Cells (hiPSCs)-derived NSCs, depicting receptor’s signaling and its dysregulation in the presence of toxic Amyloid- β in human neuronal cells. Conclusions By unraveling the pleiotropic mechanisms underlying p75NTR activation in adult neurogenesis, our research seeks to offer insights into novel mechanism of action for this neurotrophin receptor, providing potential therapeutic targets for addressing AD-related neurogenesis deficits.
Published in
p75 neurotrophin receptor shapes the dynamics of adult hippocampal neurogenesis in Alzheimer's disease
Papadopoulou MA, Chanoumidou K, Peteinareli M et al. · Alzheimer's research & therapy 2026 · PMID 41721384 · doi:10.1186/s13195-026-01989-7
This dataset
Open GSE296390 in finder → Find more mouse RNA-seq datasets →
Download · which file do I need?

Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.

1 · Just have a look

Processed table

The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.

Series matrix ↓
2 · Re-analyse it

Supplementary files

The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE296390_RAW.tar (it can run to tens of gigabytes).

All supplementary files ↗ Whole study · RAW.tar ↓
3 · Start from the raw reads

Raw sequencing reads

The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.

Raw reads on ENA ↗

What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.

Also filed as BioProject PRJNA1259041 and SRA study SRP583154. Searching any of these in the dataset finder brings you back here.

NCBI GEO page ↗ Paper (PMID 41721384) ↗
Study design
3 × Hippocampal tissue, WT, biol vs 3 × Hippocampal tissue, 5xFAD, biol vs 3 × Hippocampal tissue, p75NTRko, biol vs 3 × Hippocampal tissue, 5xFAD/p75NTRko, biol

Supports a between-group comparison across 12 samples.

How we read this: 4 replicated groups read from 12 sample titles; they account for 12 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.

Samples in this study
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