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HELLS is required for DNA methylation at human satellite repeats [RNA-seq]

GSE296398 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2025/06/23 Platform GPL24676
Summary
HELLS is a known chromatin remodeler, but its specific genomic targets have not been sufficiently described. Here, we report the generation of HELLS knockout human pluripotent cells and through telomere-to-telomere mapping of whole genome bisulfite sequencing data combined with ATAC-sequencing, we discovered a striking loss of DNA methylation over inaccessible, satellite repeats. Our study further clarifies the role of HELLS and provides insights into functional consequences through its deregulation in diseases.
Published in
HELLS is required for maintaining proper DNA modification at human satellite repeats
Guckelberger P, Haut L, Tornisiello R et al. · Genome biology 2025 · PMID 40676590 · doi:10.1186/s13059-025-03681-9
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Also filed as BioProject PRJNA1259059 and SRA study SRP583173. Searching any of these in the dataset finder brings you back here.

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