Crnic Institute Human Trisome Project - Trisomy 21 Model Atlas: PolyA RNA-seq from adult WT and Dp16 mouse liver tissue
RNA-seq (gene expression) · mouse · 12 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 12 samples: 12 samples, each with a distinct title — no replicated groupsGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Altered hepatic metabolism in Down syndromeCell reports · 2026
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE296420_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1259260 and SRA study SRP583290. Searching any of these in the dataset finder brings you back here.
Any grouping that defines a comparison lives in the sample characteristics, which GEO records separately from the titles.
How we read this: Read from 12 sample titles: 12 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8970167 Wild-type C57BL/6J; Sample_WT_173_13422_Lv
- GSM8970168 Wild-type C57BL/6J; Sample_WT_179_13423_Lv
- GSM8970169 Wild-type C57BL/6J; Sample_WT_184_13425_Lv
- GSM8970170 Wild-type C57BL/6J; Sample_WT_192_13427_Lv
- GSM8970171 Wild-type C57BL/6J; Sample_WT_195_13427_Lv
- GSM8970172 Wild-type C57BL/6J; Sample_WT_203_13429_Lv
- GSM8970173 Dp16; Sample_Dp16_175_13423_Lv
- GSM8970174 Dp16; Sample_Dp16_183_13425_Lv
- GSM8970175 Dp16; Sample_Dp16_188_13426_Lv
- GSM8970176 Dp16; Sample_Dp16_193_13427_Lv
- GSM8970177 Dp16; Sample_Dp16_194_13427_Lv
- GSM8970178 Dp16; Sample_Dp16_202_13429_Lv
- GSE296500 Crnic Institute Human Trisome Project - Trisomy 21 Model Atlas: PolyA RNA-seq from adult WT and Dp16 mouse liver tissue ± high fat diet 45 samples shares dp16, institute, trisome, project, trisomy, rna-seq, crnic, polya
- GSE296720 Crnic Institute Human Trisome Project - Trisomy 21 Model Atlas: Single cell fixed RNA profiling from 4-month old WT and Dp16 mouse liver tissue 1 samples shares dp16, institute, trisome, project, trisomy, crnic
- GSE272694 Crnic Institute - Trisomy 21 Model Atlas: PolyA RNA-seq from 6-month old mouse brain hippocampus tissue ± JAK1/3 inhibition with tofacitinib 34 samples shares institute, trisomy, rna-seq, crnic, polya
- GSE272693 Crnic Institute - Trisomy 21 Model Atlas: PolyA RNA-seq from 6-month old mouse brain cortex tissue ± JAK1/3 inhibition with tofacitinib 34 samples shares institute, trisomy, rna-seq, crnic, polya
- GSE272572 Crnic Institute - Trisomy 21 Model Atlas: PolyA RNA-seq from adult mouse spleen tissue 18 samples shares institute, trisomy, rna-seq, crnic, polya
- GSE272570 Crnic Institute - Trisomy 21 Model Atlas: PolyA RNA-seq from adult mouse liver tissue 18 samples shares institute, trisomy, rna-seq, crnic, polya
- GSE272569 Crnic Institute - Trisomy 21 Model Atlas: PolyA RNA-seq from adult mouse kidney tissue 18 samples shares institute, trisomy, rna-seq, crnic, polya
- GSE272568 Crnic Institute - Trisomy 21 Model Atlas: PolyA RNA-seq from adult mouse brain cortex 18 samples shares institute, trisomy, rna-seq, crnic, polya
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.