Crnic Institute Human Trisome Project - Trisomy 21 Model Atlas: Single cell fixed RNA profiling from 4-month old WT and Dp16 mouse liver tissue
Single-cell RNA-seq · mouse · 1 samples
- What it is
- Single-cell RNA-seqGene activity measured in thousands of individual cells, so cell types can be told apart.
- Organism
- Mus musculus (mouse)
- Samples
- 1 samples
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Altered hepatic metabolism in Down syndromeCell reports · 2026
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE296720_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Single-cell studies usually ship their counts as 10x files (matrix.mtx, barcodes.tsv, features.tsv), an .h5 file, or an .rds / .h5ad object that Seurat or Scanpy can open. Look for those among the supplementary files.
Also filed as BioProject PRJNA1260925 and SRA study SRP584175. Searching any of these in the dataset finder brings you back here.
The sample list for this study is not cached yet. Press Load samples and it will be fetched from NCBI.
+ 1 more — browse all 1 samples with per-sample file links →
- GSE296500 Crnic Institute Human Trisome Project - Trisomy 21 Model Atlas: PolyA RNA-seq from adult WT and Dp16 mouse liver tissue ± high fat diet 45 samples shares dp16, institute, trisome, project, trisomy, crnic
- GSE296420 Crnic Institute Human Trisome Project - Trisomy 21 Model Atlas: PolyA RNA-seq from adult WT and Dp16 mouse liver tissue 12 samples shares dp16, institute, trisome, project, trisomy, crnic
- GSE272694 Crnic Institute - Trisomy 21 Model Atlas: PolyA RNA-seq from 6-month old mouse brain hippocampus tissue ± JAK1/3 inhibition with tofacitinib 34 samples shares institute, trisomy, crnic
- GSE272693 Crnic Institute - Trisomy 21 Model Atlas: PolyA RNA-seq from 6-month old mouse brain cortex tissue ± JAK1/3 inhibition with tofacitinib 34 samples shares institute, trisomy, crnic
- GSE272572 Crnic Institute - Trisomy 21 Model Atlas: PolyA RNA-seq from adult mouse spleen tissue 18 samples shares institute, trisomy, crnic
- GSE272570 Crnic Institute - Trisomy 21 Model Atlas: PolyA RNA-seq from adult mouse liver tissue 18 samples shares institute, trisomy, crnic
- GSE272569 Crnic Institute - Trisomy 21 Model Atlas: PolyA RNA-seq from adult mouse kidney tissue 18 samples shares institute, trisomy, crnic
- GSE272568 Crnic Institute - Trisomy 21 Model Atlas: PolyA RNA-seq from adult mouse brain cortex 18 samples shares institute, trisomy, crnic
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.