CK2α deletion in the hematopoietic compartment leads to mild alterations in terminally differentiated cells and expansion of stem cells
RNA-seq (gene expression) · mouse · 22 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 22 samples: 22 samples, each with a distinct title — no replicated groupsGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Lineage-specific CK2α deletion reshapes the transcriptome of hematopoietic stem cells toward an immune-primed statebioRxiv : the preprint server for biology · 2026
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE296499_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1259508 and SRA study SRP583397. Searching any of these in the dataset finder brings you back here.
Any grouping that defines a comparison lives in the sample characteristics, which GEO records separately from the titles.
How we read this: Read from 22 sample titles: 22 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8971719 Control mouse 266 bone marrow
- GSM8971720 Control mouse 266 spleen
- GSM8971721 Control mouse 272 bone marrow
- GSM8971722 Control mouse 272 spleen
- GSM8971723 Control mouse 387 bone marrow
- GSM8971724 Control mouse 387 spleen
- GSM8971725 Control mouse 660 bone marrow
- GSM8971726 Control mouse 660 spleen
- GSM8971727 CK2a double knock-out mouse 382 bone marrow
- GSM8971728 CK2a double knock-out mouse 382 spleen
- GSM8971729 CK2a double knock-out mouse 383 bone marrow
- GSM8971730 CK2a double knock-out mouse 383 spleen
- GSM8971731 CK2a double knock-out mouse 384 bone marrow
- GSM8971732 CK2a double knock-out mouse 384 spleen
- GSM8971733 CK2a double knock-out mouse 660 bone marrow
- GSM8971734 CK2a double knock-out mouse 660 spleen
- GSM8971735 CK2a single knock-out mouse 545 bone marrow
- GSM8971736 CK2a single knock-out mouse 545 spleen
- GSM8971737 CK2a single knock-out mouse 552 bone marrow
- GSM8971738 CK2a single knock-out mouse 552 spleen
- GSM8971739 CK2a single knock-out mouse 555 bone marrow
- GSM8971740 CK2a single knock-out mouse 555 spleen
- GSE286398 Lysine-specific demethylase 1 regulates hematopoietic stem cell expansion and myeloid cell differentiation [scRNA-seq] 13 samples shares hematopoietic, expansion
- GSE288012 Genome-wide screen identifies Runx2 as a novel regulator of hematopoietic stem cell expansion and T-cell commitment 20 samples shares hematopoietic, expansion
- GSE200103 CK2 phosphorylation of cap methyltransferase CMTR1 promotes RNAPII interaction 12 samples shares ck2
- GSE274544 Single cell profiling reveals three endothelial to hematopoietic transitions with divergent isoform expression landscapes [scRNA-Seq] 1494 samples shares hematopoietic
- GSE309052 The TCR-SUB1-DOCK2 Signaling Axis Governs Autoimmunity by Regulating CD4+ T Cell Migratory Capacity 14 samples shares ck2
- GSE265909 yHSC and oHSC scRNAseq with oHSC AThi ATlo Index Sorting. Assessing the transcriptional changes associated with autophagy engagement in old hematopoietic stem cells at single cell resolution. [scRNA-Seq] 563 samples shares hematopoietic
- GSE285231 Systems genetics reveals the influence of eQTLs in mouse embryonic stem cells on transcriptional variation later in differentiated neural progenitor cells 186 samples shares differentiated
- GSE75111 Single-cell transcriptional profiling of Th17 cells, differentiated in vitro for 48h [TGFB1_IL6-48h-IL-17A/GFP+] 151 samples shares differentiated
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.