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Endogenous retroviruses promote aberrant T cell differentiation in systemic lupus erythematosus via the RIG-I pathway [mouse_CD4]

GSE296556 Mus musculus Expression profiling by high throughput sequencing 8 samples Submitted 2025/11/18 Platform GPL24247
Summary
The dysregulated differentiation of T lymphocytes play an important role in systemic lupus erythematosus (SLE). However, the underlying mechanism remains unclear. Here, we screened for differentially expressed genes in CD4+T cells derived from WT and DDX58 KO mice by RNA-seq. And our findings reveal the roles and mechanism of RIG-I in regulating the aberrant differentiation of T cells in SLE patients.
Published in
DNA demethylation mediated endogenous retroviruses transcription promotes aberrant T cell differentiation in systemic lupus erythematosus via RIG-I pathway
Min X, Yu Y, Hu Z et al. · EBioMedicine 2025 · PMID 40992212 · doi:10.1016/j.ebiom.2025.105934
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Also filed as BioProject PRJNA1259979 and SRA study SRP583718. Searching any of these in the dataset finder brings you back here.

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