GEO series
Transcriptional characterisation of skin tissues from photoaged mice and mice treated with alpha-ketobutyrate (α-KB).
GSE296578
Mus musculus
Expression profiling by high throughput sequencing
24 samples
2025/05/31
GPL24247
Summary
The skin is the largest organ in the human body and due to the inevitable exposure to the external environment, over time and the accumulation of various stimuli, the skin will undergo photoaging. Our study has shown that metabolite alpha-ketobutyrate (α-KB) in the transsulfuration pathway has an ameliorating effect on photoaging in mouse skin tissue. We used RNA-Seq analysis to investigate the transcriptional profiles of skin tissue from photoaged and α-KB-treated mice to elucidate the molecular mechanisms by which α-KB improves skin organisation in mice.
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