RESTORATION OF NOX4 SIGNALLING REVERSES ENDOTHELIAL COLONY-FORMING CELL ANGIOGENIC DYSFUNCTION ASSOCIATED WITH EXPERIMENTAL AND CLINICAL DIABETES
RNA-seq (gene expression) · human · 11 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Samples
- 11 samples: 6 × CB-ECFC cells, Healthy vs 5 × CB-ECFC cells, DiabeticGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Restoration of NOX4 signalling reverses endothelial colony-forming cell angiogenic dysfunction associated with experimental and clinical diabetesStem cell research & therapy · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE296585_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1260015 and SRA study SRP583665. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 11 samples.
How we read this: 2 replicated groups read from 11 sample titles; they account for 11 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8972915 CB-ECFC cells, Healthy1 CB-ECFC cells, Healthy
- GSM8972916 CB-ECFC cells, Diabetic1 CB-ECFC cells, Diabetic
- GSM8972917 CB-ECFC cells, Healthy2 CB-ECFC cells, Healthy
- GSM8972918 CB-ECFC cells, Diabetic2 CB-ECFC cells, Diabetic
- GSM8972919 CB-ECFC cells, Healthy3 CB-ECFC cells, Healthy
- GSM8972920 CB-ECFC cells, Diabetic3 CB-ECFC cells, Diabetic
- GSM8972921 CB-ECFC cells, Healthy4 CB-ECFC cells, Healthy
- GSM8972922 CB-ECFC cells, Healthy5 CB-ECFC cells, Healthy
- GSM8972923 CB-ECFC cells, Diabetic5 CB-ECFC cells, Diabetic
- GSM8972924 CB-ECFC cells, Healthy6 CB-ECFC cells, Healthy
- GSM8972925 CB-ECFC cells, Diabetic6 CB-ECFC cells, Diabetic
- GSE309967 Immunometabolic Endotypes Define Distinct Clinical Trajectories in Type 2 Diabetes 48 samples shares clinical, diabetes
- GSE309941 Immunometabolic Endotypes Define Distinct Clinical Trajectories in Type 2 Diabetes [bulk RNA-seq] 42 samples shares clinical, diabetes
- GSE316742 SGLT2 inhibition reverses metabolic and inflammatory kidney signatures in youth with type 1 diabetes 27 samples shares reverses, diabetes
- GSE314188 Responders to low-dose ATG induce CD4+ T cell exhaustion in type 1 diabetes 514 samples shares diabetes
- GSE49711 RNA-Seq reveals an unprecedented complexity of the neuroblastoma transcriptome and is suitable for clinical endpoint prediction [RNA-Seq] 498 samples shares clinical
- GSE297413 Genomic and transcriptomic determinants of clinical outcomes in patients with AML and DNMT3A mutations 264 samples shares clinical
- GSE263733 Single-cell transcriptome analysis reveals subtype-specific clonal evolution and microenvironmental changes in liver metastasis of pancreatic adenocarcinoma and their clinical implications 218 samples shares clinical
- GSE280267 Glycine Receptor Activity in β Cells Is Downregulated in Type 2 Diabetes and After High Glucose Culture 199 samples shares diabetes
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.