Evaluation of cellular distribution of intravenously injected LNP in the skeletal muscle
RNA-seq (gene expression) · mouse · 10 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 10 samples: 10 samples, each with a distinct title — no replicated groupsGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE296617_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1260241 and SRA study SRP583803. Searching any of these in the dataset finder brings you back here.
Any grouping that defines a comparison lives in the sample characteristics, which GEO records separately from the titles.
How we read this: Read from 10 sample titles: 10 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8973662 PBS_Bulk
- GSM8973663 iv LNP-Luc_Bulk
- GSM8973664 PBS_Satellite cell
- GSM8973665 iv LNP-Luc_Satellite cell
- GSM8973666 im LNP-Luc_Bulk
- GSM8973667 PBS-2_Bulk
- GSM8973668 iv AAV-Luc_Bulk
- GSM8973669 im LNP-Luc_Satellite cell
- GSM8973670 PBS-2_Satellite cell
- GSM8973671 iv AAV-Luc_Satellite cell
- GSE269943 Evaluation of cellular distribution of LNP-CRISPR in the skeletal muscle 4 samples shares lnp, distribution, evaluation, cellular, skeletal, muscle
- GSE331154 Bulk RNA sequencing from liver of mice injected with saline or mRNA-LNPs encoding eGFP, 10ug dose, 24h timepoint, intravenous route. 10 samples shares lnp, injected
- GSE264111 Bulk RNA-seq of microglia from Apoa1 KO mice injected with ApoA-I protein intravenously 16 samples shares intravenously, injected
- GSE273582 Evaluation of bovine colostrum extracellular vesicles on NASH mouse model 8 samples shares evaluation, cellular
- GSE253570 Molecular signatures and spatial distribution of disease-associated cellular populations in early-onset Alzheimer's disease mouse brain 12 samples shares distribution, cellular
- GSE291607 The effect of miR192-LNP on the regulation of innate immune response 18 samples shares lnp
- GSE207141 Prototype LNP-mRNA vaccine candidates [SC_RNAseq] 14 samples shares lnp
- GSE319665 RNA-seq of tumors from mice treated with FPC (5-FU, anti-PD-1 antibody, and anti-CTLA-4 antibody), mRNA–LNP and KDM5B inhibitors. 6 samples shares lnp
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.