Modulation of inflammatory responses in mouse models of pericyte-depletion retinopathy
RNA-seq (gene expression) · mouse · 12 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 12 samples: 12 samples, each with a distinct title — no replicated groupsGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Immunomodulation of inflammatory responses preserves retinal integrity in murine models of pericyte-depletion retinopathyJCI insight · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE296651_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1260457 and SRA study SRP583865. Searching any of these in the dataset finder brings you back here.
Any grouping that defines a comparison lives in the sample characteristics, which GEO records separately from the titles.
How we read this: Read from 12 sample titles: 12 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8974269 IgG_Ctrl_1_C57BL6/J_Retina
- GSM8974270 IgG_Ctrl_2_C57BL6/J_Retina
- GSM8974271 IgG_Ctrl_3_C57BL6/J_Retina
- GSM8974272 IgG_Mino_1_C57BL6/J_Retina
- GSM8974273 IgG_Mino_2_C57BL6/J_Retina
- GSM8974274 IgG_Mino_3_C57BL6/J_Retina
- GSM8974275 APB5_1_C57BL6/J_Retina
- GSM8974276 APB5_2_C57BL6/J_Retina
- GSM8974277 APB5_3_C57BL6/J_Retina
- GSM8974278 APB5_Mino_1_C57BL6/J_Retina
- GSM8974279 APB5_Mino_2_C57BL6/J_Retina
- GSM8974280 APB5_Mino_3_C57BL6/J_Retina
- GSE298388 Modulation of Inflammatory Pain by Myeloid FABP5 12 samples shares modulation
- GSE241879 Extensive modulation of inflammatory and axonal genes led to robust axon regeneration in severe benzalkonium chloride-injured corneas treated with cord blood-derived biologics 12 samples shares modulation
- GSE238218 A combination treatment based on drug repurposing demonstrates mutation agnostic efficacy in pre-clinical retinopathy models. 40 samples shares retinopathy
- GSE266470 Selective targeting and modulation of plaque associated microglia via systemic hydroxyl dendrimer administration in an Alzheimer’s disease mouse model. 32 samples shares modulation
- GSE238217 A combination treatment based on drug repurposing demonstrates mutation agnostic efficacy in pre-clinical retinopathy models. [RNA-seq: Rd10] 24 samples shares retinopathy
- GSE243170 LTBR-mediated immunomodulation of the tumor microenvironment promotes anti-tumor responses 20 samples shares modulation
- GSE294347 Rationalistic Modulation of Immune Mechanisms Synergizes the Anti-Tumor Effects of Targeted Radiation Therapy in Pre-clinical Models 14 samples shares modulation
- GSE243692 Small molecule probe for IBD risk variant GPR65 I231L alters cytokine signaling networks through positive allosteric modulation 90 samples shares modulation
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.