GEO series
Plaque-induced transcriptional reprogramming of microglia towards lymphoid receptor expression protects against Alzheimer's disease [scRNA-seq]
GSE296768
Mus musculus
Expression profiling by high throughput sequencing
12 samples
2025/08/07
GPL17021
Summary
Amyloid plaque associated microglia induce a transcriptional state characterized by downregulation of the transcription factor Spi1 and upregulation of a subset of canonically lymphoid-specific signaling genes. Knockout of one such gene, Cd28, in microglia exacerbates interferon-responses in response to amyloid pathology.
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Paper (PMID 41193812) ↗
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