RNA-Seq analysis of high-fiber diets and caloric restriction in mouse liver
RNA-seq (gene expression) · mouse · 36 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 36 samples: 6 conditions, mostly with about 6 replicates eachGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- A high-fiber diet mimics aging-related signatures of caloric restriction in mammalsNature communications · 2025
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE296874_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1261862 and SRA study SRP584719. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 36 samples.
How we read this: 6 replicated groups read from 36 sample titles; they account for 36 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8979114 liver, CR1 liver, C
- GSM8979115 liver, CR2 liver, C
- GSM8979116 liver, CR3 liver, C
- GSM8979117 liver, CR4 liver, C
- GSM8979118 liver, CR5 liver, C
- GSM8979119 liver, CR6 liver, C
- GSM8979120 liver, CF1 liver, CF
- GSM8979121 liver, CF2 liver, CF
- GSM8979122 liver, CF3 liver, CF
- GSM8979123 liver, CF4 liver, CF
- GSM8979124 liver, CF5 liver, CF
- GSM8979125 liver, CF6 liver, CF
- GSM8979126 liver, CFm1 liver, CFm
- GSM8979127 liver, CFm2 liver, CFm
- GSM8979128 liver, CFm3 liver, CFm
- GSM8979129 liver, CFm4 liver, CFm
- GSM8979130 liver, CFm5 liver, CFm
- GSM8979131 liver, CFm6 liver, CFm
- GSM8979132 liver, IFm1 liver, IFm
- GSM8979133 liver, IFm2 liver, IFm
- GSM8979134 liver, IFm3 liver, IFm
- GSM8979135 liver, IFm4 liver, IFm
- GSM8979136 liver, IFm5 liver, IFm
- GSM8979137 liver, IFm6 liver, IFm
- GSM8979138 liver, IF1 liver, IF
- GSM8979139 liver, IF2 liver, IF
- GSM8979140 liver, IF3 liver, IF
- GSM8979141 liver, IF4 liver, IF
- GSM8979142 liver, IF5 liver, IF
- GSM8979143 liver, IF6 liver, IF
- GSM8979144 liver, RD1 liver, RD
- GSM8979145 liver, RD2 liver, RD
- GSM8979146 liver, RD3 liver, RD
- GSM8979147 liver, RD4 liver, RD
- GSM8979148 liver, RD5 liver, RD
- GSM8979149 liver, RD6 liver, RD
- GSE248297 Liver RNA-seq from male C57Bl/6J on a ketogenic diet 15 samples shares rna-seq, liver
- GSE331228 RNA-seq profiling of liver and lung of CLP mice(6h) 12 samples shares rna-seq, liver
- GSE248866 The outcomes of caloric restriction are driven by enhanced glucocorticoid rhythms. 114 samples shares restriction, caloric
- GSE326100 scRNA-seq of mouse cochlea organoid cells 768 samples shares rna-seq
- GSE311449 Single cell RNA-seq of mouse brain vascular cells with Smart-seq2 method 391 samples shares rna-seq
- GSE319614 Bulk RNA-seq transcriptome profiling of hippocampus across 17 autism spectrum disorder mouse models 269 samples shares rna-seq
- GSE326452 Bulk RNA-seq of mouse brain following closed head injury: role of IL-1R1 signaling 200 samples shares rna-seq
- GSE264105 Plate-based scRNA-seq of plasma-positive microglia and plasma-negative microglia in young mice 1111 samples shares rna-seq
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.