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The RNA-Binding Protein DDX39B Promotes Colorectal Adenocarcinoma Progression by Stabilizing DCLK1

GSE296923 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2025/06/22 Platform GPL24676
Summary
As an RNA-binding protein (RBP), DDX39B increased the stability of DCLK1-B mRNA, a variant highly expressed in colorectal cancer known to promote cancer stemness, thereby augmenting its protein expression. Notably, silencing of DCLK1-B effectively abrogated the pro-metastatic effects induced by DDX39B overexpression.
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Also filed as BioProject PRJNA1261940 and SRA study SRP584648. Searching any of these in the dataset finder brings you back here.

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