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ZFP148 is a transcriptional regulator of effector CD8+ T cell differentiation [single-cell_multiome]

GSE297040 Mus musculus Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing 4 samples Submitted 2026/02/02 Platform GPL34290
Summary
Chronic antigen exposure, as seen in persistent viral infections and cancer, drives CD8⁺ T cells to differentiate into diverse subsets: progenitor/stem-like, effector, and exhausted/dysfunctional cells. While genetic and epigenetic factors influencing these subsets are known, the mechanisms regulating their dynamic balance remain unclear. We identified Zinc-Finger Protein 148 (ZFP148) as a novel transcriptional checkpoint in CD8⁺ T cell effector differentiation. Using a genetic approach that deletes ZFP148 specifically in CD8+ T cells, we performed matched single cell RNA-seq and ATAC-seq on antigen-specific CD8+ T cells.
Published in
ZFP148 is a transcriptional repressor of cytolytic effector CD8(+) T cell differentiation
Xiao T, Chen X, Song NJ et al. · Nature immunology 2026 · PMID 41896465 · doi:10.1038/s41590-026-02461-2
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Also filed as BioProject PRJNA1262431 and SRA study SRP585080. Searching any of these in the dataset finder brings you back here.

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