Distinct Molecular Responses of Human Intestinal Organoids to Proton and Photon Radiation
RNA-seq (gene expression) · human · 40 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Samples
- 40 samples: 40 samples, each with a distinct title — no replicated groupsGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Distinct molecular responses of human intestinal organoids to proton and photon radiationAmerican journal of physiology. Gastrointestinal and liver physiology · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE297090_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1262498 and SRA study SRP584993. Searching any of these in the dataset finder brings you back here.
Any grouping that defines a comparison lives in the sample characteristics, which GEO records separately from the titles.
How we read this: Read from 40 sample titles: 40 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8983526 J8 villus like HIO proton irradiated
- GSM8983527 J8 villus like HIO gamma irradiated
- GSM8983528 J8 villus like HIO proton mock-irradiated
- GSM8983529 J8 villus like HIO gamma mock-irradiated
- GSM8983530 J8 crypt like HIO proton irradiated
- GSM8983531 J8 crypt like HIO gamma irradiated
- GSM8983532 J8 crypt like HIO proton mock-irradiated
- GSM8983533 J8 crypt like HIO gamma mock-irradiated
- GSM8983534 J6 villus like HIO proton irradiated
- GSM8983535 J6 villus like HIO gamma irradiated
- GSM8983536 J6 villus like HIO proton mock-irradiated
- GSM8983537 J6 villus like HIO gamma mock-irradiated
- GSM8983538 J6 crypt like HIO proton irradiated
- GSM8983539 J6 crypt like HIO gamma irradiated
- GSM8983540 J6 crypt like HIO proton mock-irradiated
- GSM8983541 J6 crypt like HIO gamma mock-irradiated
- GSM8983542 J3 villus like HIO proton irradiated
- GSM8983543 J3 villus like HIO gamma irradiated
- GSM8983544 J3 villus like HIO proton mock-irradiated
- GSM8983545 J3 villus like HIO gamma mock-irradiated
- GSM8983546 J3 crypt like HIO proton irradiated
- GSM8983547 J3 crypt like HIO gamma irradiated
- GSM8983548 J3 crypt like HIO proton mock-irradiated
- GSM8983549 J3 crypt like HIO gamma mock-irradiated
- GSM8983550 J2 villus like HIO proton irradiated
- GSM8983551 J2 villus like HIO gamma irradiated
- GSM8983552 J2 villus like HIO proton mock-irradiated
- GSM8983553 J2 villus like HIO gamma mock-irradiated
- GSM8983554 J2 crypt like HIO proton irradiated
- GSM8983555 J2 crypt like HIO gamma irradiated
- GSM8983556 J2 crypt like HIO proton mock-irradiated
- GSM8983557 J2 crypt like HIO gamma mock-irradiated
- GSM8983558 J11 villus like HIO proton irradiated
- GSM8983559 J11 villus like HIO gamma irradiated
- GSM8983560 J11 villus like HIO proton mock-irradiated
- GSM8983561 J11 villus like HIO gamma mock-irradiated
- GSM8983562 J11 crypt like HIO proton irradiated
- GSM8983563 J11 crypt like HIO gamma irradiated
- GSM8983564 J11 crypt like HIO proton mock-irradiated
- GSM8983565 J11 crypt like HIO gamma mock-irradiated
- GSE308421 Single-Cell RNA Sequencing Analysis of Intestinal organoids expanded in either IntestiCult™ Plus or IntestiCult™ OGM (Human) 10 samples shares intestinal, organoids
- GSE319130 Multi-omic analysis reveals molecular subtypes with distinct immunological phenotypes in SLE [RNA-Seq] 804 samples shares distinct
- GSE130970 Gene expression predicts histological severity and reveals distinct molecular profiles of nonalcoholic fatty liver disease 78 samples shares distinct
- GSE280480 Gene expression profiling reveals two overarching types of anaplastic large cell lymphoma with distinct targetable biology: an LLMPP study 393 samples shares distinct
- GSE315442 Transcriptomic profiling reveals distinct molecular signatures among lesion types in hidradenitis suppurativa 48 samples shares distinct
- GSE282696 DISTINCTIVE MOLECULAR SIGNATURE AND STRUCTURAL ALTERATIONS OF THE COLONIC BRUSH BORDER IN MICROSCOPIC COLITIS 48 samples shares distinct
- GSE288617 Paired transcriptomics reveals similarities between cytokine-stimulated organoids and ulcerative colitis epithelial responses 41 samples shares organoids
- GSE313368 Dictionary of human intestinal organoid responses to secreted niche factors at single cell resolution 39 samples shares intestinal
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.