Mitochondrial RNA degradation is increased in AML and controls differentiation, stem cell function and sensitivity to immune-mediated killing
Expression microarray · human · 22 samples
- What it is
- Expression microarrayGene activity read on a chip (the older technology that RNA-seq replaced).
- Organism
- Homo sapiens (human)
- Samples
- 22 samples: 6 conditions, mostly with about 4 replicates eachGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed expression table (series matrix) and the array files, from NCBI.
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE297114_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For arrays the series matrix is normally the normalised expression table you want; the raw array files (CEL and similar) are in the RAW.tar.
Also filed as BioProject PRJNA1262733 and SRA study SRP585162. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 21 samples.
How we read this: 6 replicated groups read from 22 sample titles; they account for 21 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8982711 PNPT 545 day3 PNPT 545 day
- GSM8982712 PNPT 545 day4 PNPT 545 day
- GSM8982713 PNPT 545 day5 PNPT 545 day
- GSM8982714 PNPT 545 day6 PNPT 545 day
- GSM8982715 PNPT 1717 day3 PNPT 1717 day
- GSM8982716 PNPT 1717 day4 PNPT 1717 day
- GSM8982717 PNPT 1717 day5 PNPT 1717 day
- GSM8982718 PNPT 1717 day6 PNPT 1717 day
- GSM8982719 SUV 1595 day 3 SUV 1595 day
- GSM8982720 SUV 1595 day4 SUV 1595 day
- GSM8982721 SUV 1595_day5
- GSM8982722 SUV 1595 day 6 SUV 1595 day
- GSM8982723 SUV 1727 day 3 SUV 1727 day
- GSM8982724 SUV 1727 day4 SUV 1727 day
- GSM8982725 SUV 1727 day5 SUV 1727 day
- GSM8982726 SUV 1727 day 6 SUV 1727 day
- GSM8984048 IP_ed_PNPT1_545 IP_ed_PNPT1
- GSM8984049 IP_ed_PNPT1_1717 IP_ed_PNPT1
- GSM8984050 IP_ed_PNPT1_1979 IP_ed_PNPT1
- GSM8984051 IP_ed_SUV3_566 IP_ed_SUV3
- GSM8984052 IP_ed_SUV3_1595 IP_ed_SUV3
- GSM8984053 IP_ed_SUV3_1727 IP_ed_SUV3
- GSE327386 RNA-Seq of paired diagnosis and relapse AML specimens with healthy controls 130 samples shares aml, controls
- GSE211032 Expression Analysis (RNA-Seq) of adult Myelodysplastic Syndromes (MDS)/Acute Myeloid Leukemia (AML) with isolated monosomy 7 compared to controls 45 samples shares aml, controls
- GSE291860 Achilles tendon exhibits distinct transcriptomic changes with increased mitochondrial energy production under lunar gravity 18 samples shares mitochondrial, increased
- GSE327103 Glabridin Promotes Melanosome Degradation and Alleviates Melanosome-Induced Mitochondrial Dysfunction in Keratinocytes via Autophagy 9 samples shares mitochondrial, degradation
- GSE256353 Upregulated cholesterol biosynthesis facilitates the survival of methylation-retaining AML cells following decitabine treatment [single_colony_TEM-Seq] 1728 samples shares aml
- GSE232130 Leucegene: AML sequencing (GRCh38 reference) 691 samples shares aml
- GSE232129 Leucegene: AML sequencing (part 1-6, GRCh38 reference) 452 samples shares aml
- GSE297413 Genomic and transcriptomic determinants of clinical outcomes in patients with AML and DNMT3A mutations 264 samples shares aml
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.