← BioTransfer GEO Dataset Finder
GEO series

Interplay between Genetic Variation and Nutrition Challenge Controls Hepatic Diurnal Rhythms [ATAC-seq]

GSE297115 Mus musculus Genome binding/occupancy profiling by high throughput sequencing 6 samples Submitted 2025/08/25 Platform GPL19057
Summary
Variation in diurnal rhythms contributes to the risk of multiple diseases, yet the genomic and epigenomic basis remains largely unknown. Here, we show that SNPs in enhancer and promoter regions genome-wide contribute to variations in human diurnal rhythms. Differential rhythmic gene expression and physiological responses to diet-induced obesity in mice with different genetic backgrounds are linked to time-dependent enhancer-promoter interactions (EPI) regulated by cis-regulatory SNPs and transcription factors (TFs) like ESRRγ. Hepatocyte-specific Esrrγ knockout alters rhythmic processes in liver, including triglyceride synthesis and lipid droplet formation, across mouse strains. Moreover, motifs of ESRRγ and other lipid metabolism-related TFs are enriched in individual-specific EPIs harboring SNPs to control rhythmic genes in patients with MAFLD. SNPs located in these sites are correlated with hepatic metabolic traits. Thus, SNPs and TFs interdependently form the genomic and epigenomic basis for diurnal rhythm variation, contributing to disease risk.
Published in
Genetics-nutrition interactions control diurnal enhancer-promoter dynamics and liver lipid metabolism
Zhou D, Chen Y, Liu P et al. · Cell metabolism 2025 · PMID 40858101 · doi:10.1016/j.cmet.2025.07.010
This dataset
Download

Direct links to NCBI, no account and no request form: the whole study as GSE297115_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 6 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1262740 and SRA study SRP585163. Searching any of these in the dataset finder brings you back here.

Samples in this study

The sample list for this study is not cached yet. Press Sort into groups and it will be fetched from NCBI.

+ 6 more — browse all 6 samples with per-sample file links →

Similar datasets

Search all mouse ChIP / ATAC / CUT&Tag datasets in GEO →

Share this dataset

Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.