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Comprehensive Transcriptome Profiling Unveils the Oncolytic Mechanisms of Newcastle Disease Virus on Colonic Carcinoma

GSE297244 Homo sapiens Expression profiling by high throughput sequencing 8 samples Submitted 2025/09/03 Platform GPL16791
Summary
Viral oncolysis is supposed to be a promising cancer treatment method because of its good tolerability and durable anti-tumor effects. Compared with other oncolytic viruses, newcastle disease virus (NDV) has some distinct advantages, namely, NDV is a RNA virus which can not recombine with the host genome, making it safer compared to DNA viruses and retroviruses; NDV can induce syncytium formation, allowing the virus to spread between cells without exposure to host neutralizing antibodies; because of hexamer genetic code rule, NDV genome has an lower rate of gene recombination and higher genetic stability. This study systematically investigates the oncolytic mechanism of NDV against colonic carcinoma on transcriptional level and provides theoretical foundations for developing NDV-based therapies targeting colon cancer.
Published in
Genome-Wide Screening Reveals the Oncolytic Mechanism of Newcastle Disease Virus in a Human Colonic Carcinoma Cell Line
Zhang Y, Feng S, Yi G et al. · Viruses 2025 · PMID 40872758 · doi:10.3390/v17081043
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Direct links to NCBI, no account and no request form: the whole study as GSE297244_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 8 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1263388 and SRA study SRP585646. Searching any of these in the dataset finder brings you back here.

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