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Effect of circ72039 overexpression on gene expression related to gemcitabine sensitivity in pancreatic cancer cell lines

GSE297252 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2025/11/15 Platform GPL28038
Summary
Understanding the molecular characteristics of gemcitabine sensitivity in pancreatic cancer is essential for advancing individualized treatment strategies. This study identifies circ720309 as a potential contributor to improve gemcitabine sensitivity. circ72309 decreased cytidine deaminase, a nucleoside enzyme which transforms gemcitabine into an inactive form, via reactive oxygen species activity, and increased solute carrier family 29 member 1 (SLC29A1), a nucleoside transporter which imports gemcitabine into cells, by regulating targeted miRNAs.
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Direct links to NCBI, no account and no request form: the whole study as GSE297252_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 6 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1263404 and SRA study SRP585534. Searching any of these in the dataset finder brings you back here.

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