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TIA1-mediated stress granules promote the neurodegeneration of motor neurons through sequestrating mRNA of heat shock protein HSP70 family in C9orf72-poly-GA mice

GSE297313 Mus musculus Expression profiling by high throughput sequencing 7 samples Submitted 2025/05/16 Platform GPL24247
Summary
TIA1 knockout in the central nervous system (TIA1Nestin-CKO mice) alleviated motor neuron loss, neuroinflammation and motor dysfunction in C9orf72-poly-GA mice. Mechanistically, we performed RNA-sequencing to find the differentially expressed genes between ALS-WT and ALS-CKO mice.
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Also filed as BioProject PRJNA1263502 and SRA study SRP585598. Searching any of these in the dataset finder brings you back here.

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