GEO series
Leukemia risk factor ARID5B Coordinates HDAC-Mediated Transcriptional Repression [CUT&Run]
GSE297398
Homo sapiens
Genome binding/occupancy profiling by high throughput sequencing
47 samples
2026/05/19
GPL24676
Summary
We employed a combination of proteomics, genomics and transcriptomics to describe the molecular mechanisms of ARID5B. We identify that ARID5B interacts with MIER1, C16ORF87, HDAC1 and HDAC2 forming a repressor complex. The former localizes to active regions of the genome, tethering HDAC1 and HDAC2 to enhancers and promoters. Genes actively repressed by the ARID5B repressor complex are involved in B cell-specific signaling.
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Paper (PMID 42328790) ↗
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