Development of CAR T cells Targeting U5 snRNP200 for the Treatment of Acute Myeloid and B-Lymphoid Leukemias

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What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.

Also filed as BioProject PRJNA1263852 and SRA study SRP585965. Searching any of these in the dataset finder brings you back here.

Any grouping that defines a comparison lives in the sample characteristics, which GEO records separately from the titles.

How we read this: Read from 19 sample titles: 19 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.

• GSM8991804 RN2 cells from mice treated with control CAR T, GEX (CD45.2+/CD11b+)
• GSM8991805 RN2 cells from mice treated with control CAR T, ADT/HTO (CD45.2+/CD11b+)
• GSM8991806 Donor T cells from mice treated with control CAR T, GEX (CD45.2+/CD3+)
• GSM8991807 Donor T cells from mice treated with control CAR T, ADT/HTO (CD45.2+/CD3+)
• GSM8991808 Donor T cells from mice treated with control CAR T, TCR (CD45.2+/CD3+)
• GSM8991809 Recipient WBC from mice treated with control CAR T, GEX (CD45.1+)
• GSM8991810 Recipient WBC from mice treated with control CAR T, ADT/HTO (CD45.1+)
• GSM8991811 Recipient WBC from mice treated with control CAR T, TCR (CD45.1+)
• GSM8991812 RN2 cells from mice treated with U5 CAR T, GEX (CD45.2+/CD11b+)
• GSM8991813 RN2 cells from mice treated with U5 CAR T, ADT/HTO (CD45.2+/CD11b+)
• GSM8991814 Donor T cells from mice treated with U5 CAR T, GEX (CD45.2+/CD3+)
• GSM8991815 Donor T cells from mice treated with U5 CAR T, ADT/HTO (CD45.2+/CD3+)
• GSM8991816 Donor T cells from mice treated with U5 CAR T, TCR (CD45.2+/CD3+)
• GSM8991817 Recipient WBC from mice treated with U5 CAR T, GEX (CD45.1+)
• GSM8991818 Recipient WBC from mice treated with U5 CAR T, ADT/HTO (CD45.1+)
• GSM8991819 Recipient WBC from mice treated with U5 CAR T, TCR (CD45.1+)
• GSM8991820 WBC, GEX (CD45.1+)
• GSM8991821 WBC, ADT/HTO (CD45.1+)
• GSM8991822 WBC, TCR (CD45.1+)

• GSE250056 Targeting chemokine crosstalk between T-cells and macrophages to treat immune checkpoint inhibito-mediated myocarditis 68 samples shares car, targeting
• GSE300288 Single-cell and spatial transcriptomics analysis of tobacco-associated lung adenocarcinoma development, and in response to targeting inflammation alone or in combination with immune checkpoint blockade in precancerous phase [scRNA-seq] 31 samples shares car, targeting
• GSE291235 Effect of myeloid specific Trem2 knockout in hepatocellular carcinoma after anti-PD-1 therapy 30 samples shares car, myeloid
• GSE337190 CAR-NKT cells induce low cytokine release syndrome by targeting hyperinflammatory macrophages with mitigation from GM-SCF inhibition. 24 samples shares car, targeting
• GSE298751 Prussian blue nanoparticles targeting multiple PANoptosome-mediated PANoptosis for myocardial ischemia-reperfusion injury therapy 15 samples shares car, targeting
• GSE319694 Myeloid Piezo1 Drives Cardiac Repair Through Orai1–Rac1-Dependent Efferocytosis 10 samples shares car, myeloid
• GSE302447 A multi-functional oral small molecule targeting energy and lipid metabolism as a treatment for diet-induced obesity 67 samples shares targeting, treatment
• GSE302441 A multi-functional oral small molecule targeting energy and lipid metabolism as a treatment for diet-induced obesity [Exp 2] 16 samples shares targeting, treatment

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