Dysbiosis-induced expansion of AXL-positive inflammatory type 3 dendritic cells triggers pre-clinical autoimmunity
RNA-seq (gene expression) · mouse · 14 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 14 samples: 5 conditions, mostly in triplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE297493_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1265080 and SRA study SRP586251. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 14 samples.
How we read this: 5 replicated groups read from 14 sample titles; they account for 14 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8993135 Splenic_cDC2a_Notch2FL_R1 Splenic_cDC2a_Notch2FL
- GSM8993136 Splenic_cDC2a_Notch2FL_R2 Splenic_cDC2a_Notch2FL
- GSM8993137 Splenic_cDC2a_Notch2FL_R3 Splenic_cDC2a_Notch2FL
- GSM8993138 Splenic_DC3_Notch2FL_R1 Splenic_DC3_Notch2FL
- GSM8993139 Splenic_DC3_Notch2FL_R2 Splenic_DC3_Notch2FL
- GSM8993140 Splenic_DC3_Notch2FL_R3 Splenic_DC3_Notch2FL
- GSM8993141 Splenic_cDC1_Notch2FL_R1 Splenic_cDC1_Notch2FL
- GSM8993142 Splenic_cDC1_Notch2FL_R2 Splenic_cDC1_Notch2FL
- GSM8993143 Splenic_cDC1_Notch2FL_R3 Splenic_cDC1_Notch2FL
- GSM8993144 Splenic_DC3_Notch2cKO_R1 Splenic_DC3_Notch2cKO
- GSM8993145 Splenic_DC3_Notch2cKO_R2 Splenic_DC3_Notch2cKO
- GSM8993146 Splenic_cDC1_Notch2cKO_R1 Splenic_cDC1_Notch2cKO
- GSM8993147 Splenic_cDC1_Notch2cKO_R2 Splenic_cDC1_Notch2cKO
- GSM8993148 Splenic_cDC1_Notch2cKO_R3 Splenic_cDC1_Notch2cKO
- GSE326772 Dysbiosis-induced expansion of AXL-positive inflammatory type 3 dendritic cells triggers pre-clinical autoimmunity 6 samples shares dysbiosis-induced, axl-positive, pre-clinical, autoimmunity, expansion, dendritic, triggers, type
- GSE297642 Dysbiosis-induced expansion of AXL-positive inflammatory type 3 dendritic cells triggers pre-clinical autoimmunity 6 samples shares dysbiosis-induced, axl-positive, pre-clinical, autoimmunity, expansion, dendritic, triggers, type
- GSE296433 Engineered probiotics limit T-cell driven CNS autoimmunity by activating AHR-KLF4-FADS3 signaling in intestinal dendritic cells 40 samples shares autoimmunity, dendritic
- GSE311066 RIPK1 regulates beta-cell fate and autoimmunity in type 1 diabetes 24 samples shares autoimmunity, type
- GSE229198 Tonic type 2 immunity controls autoimmunity in the skin 12 samples shares autoimmunity, type
- GSE312237 Spatial transcriptomic profiling identifies lacrimal gland epithelial cell-driven mechanisms underlying autoimmunity in Sjögren’s disease 90 samples shares autoimmunity
- GSE222887 Cellular spermine targets JAK1 to restrain cytokine-mediated autoimmunity (Mouse) 40 samples shares autoimmunity
- GSE238218 A combination treatment based on drug repurposing demonstrates mutation agnostic efficacy in pre-clinical retinopathy models. 40 samples shares pre-clinical
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.