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Temporal and Context-Dependent Requirements for the Transcription Factor Foxp3 in Regulatory T Cell Development and Maintenance

GSE297622 Mus musculus (mouse) ChIP-seq / ATAC-seq (genome binding and open chromatin) 103 samples Submitted 2025/08/28 Platform GPL24247
At a glance

ChIP-seq / ATAC-seq (genome binding and open chromatin) · mouse · 103 samples

What it is
ChIP-seq / ATAC-seq (genome binding and open chromatin)Where proteins bind the genome, or which regions are open and active.
Organism
Mus musculus (mouse)
Samples
103 samples: 36 conditions, mostly in duplicateGroups are read from the sample names, not from the paper. Check the list below.
Data you can get
A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Paper
Temporal and context-dependent requirements for the transcription factor Foxp3 expression in regulatory T cellsNature immunology · 2025
SuperSeries — this record groups several sub-series.
Summary (written by the submitters)
This SuperSeries is composed of the SubSeries listed below.
Published in
Temporal and context-dependent requirements for the transcription factor Foxp3 expression in regulatory T cells
Hu W, Dolsten GA, Wang EY et al. · Nature immunology 2025 · PMID 41062655 · doi:10.1038/s41590-025-02295-4
This dataset
Open GSE297622 in finder → Find more mouse RNA-seq datasets →
Download · which file do I need?

Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.

1 · Just have a look

Processed table

The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.

Series matrix ↓
2 · Re-analyse it

Supplementary files

The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE297622_RAW.tar (it can run to tens of gigabytes).

All supplementary files ↗ Whole study · RAW.tar ↓
3 · Start from the raw reads

Raw sequencing reads

The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.

Raw reads on ENA ↗

What the files usually look like: Look for peak files (.bed, .narrowPeak) and signal tracks (.bigWig) among the supplementary files; the raw reads are on ENA.

Also filed as BioProject PRJNA1265460 and SRA study SRP585957. Searching any of these in the dataset finder brings you back here.

NCBI GEO page ↗ Paper (PMID 41062655) ↗
Study design
36 conditions, mostly in duplicate
Tir1 ×6 Tir1.infant ×4 WT.infant ×4 D3 TIR1 ×4 D3 WT ×4 WT ×4 Active_Treg_WT ×3 Active_Treg_TIR1 ×3 +37 more

Supports a case/control comparison: 2 samples read as cases, 15 as controls.

How we read this: 36 replicated groups read from 103 sample titles; they account for 94 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.

Samples in this study

+ 63 more — browse all 103 samples with per-sample file links →

Datasets on a similar topic

Search all mouse RNA-seq datasets in GEO →

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