GEO series

T cell receptor γδ is a critical, real-time determinant of unique tissue surveillance mechanisms

GSE297713 Homo sapiens Expression profiling by high throughput sequencing 4 samples Submitted 2026/07/21 Platform GPL24676

Summary

γδ T cells are mediators of immunosurveillance used in the clinic. However, their status remains paradoxical. While many display overt traits of adaptive immunity, several major γδ cell subsets including those in barrier tissues make rapid, seemingly TCR-independent responses phenocopying innate lymphoid cells (ILC). While such uncertainty exists, the requirements for γδ T cell-mediated immunosurveillance will remain unclear. This study resolves the paradox, showing that tissue-intrinsic γδ T cells share an absolute real-time dependence on the TCR for their phenotypes, including their so-called innate responses to tissue stress and carcinogenesis. While different tissue-intrinsic γδsubsets showed distinct TCR-dependencies, they shared a core set of TCR-regulated molecules that was likewise disrupted by acute TCR ablation in human γδ T cells. These findings unequivocally distinguish γδcells from ILC and set criteria for natural immunosurveillance that have clear implications for clinical γδ T cell-based immunotherapies.

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Direct links to NCBI, no account and no request form: the whole study as GSE297713_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 4 samples. Raw sequencing reads are also available from ENA.

Whole study · RAW.tar ↓ Series matrix ↓ All supplementary files ↗ Raw reads on ENA ↗

Also filed as BioProject PRJNA1265758 and SRA study SRP586722. Searching any of these in the dataset finder brings you back here.

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