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Spatially-patterned and functional kidney assembloids recapitulate progenitor self-assembly and enable high-fidelity in vivo disease modeling [hKPA_TT_data]

GSE297771 Homo sapiens Expression profiling by high throughput sequencing 4 samples Submitted 2025/08/13 Platform GPL24676
Summary
The paired kidneys are the central organs of homeostasis for our body systems, the sophisticated structure and complex cells composition underpins kidneys’ functions. Here we reported the generation of human kidney progenitor assembloid (KPA) with expandable nephron progenitor cells (NPC) and ureteric bud (UB). These generated hKPA showed patterned structure and included nephron, collecting duct and interstitium. More importantly, the application of TTNPB revealed the critical role of RA (retinoic acid) signaling pathway in hKPA generation.
Published in
Spatially patterned kidney assembloids recapitulate progenitor self-assembly and enable high-fidelity in vivo disease modeling
Huang B, Medina P, He J et al. · Cell stem cell 2025 · PMID 40967224 · doi:10.1016/j.stem.2025.08.013
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Also filed as BioProject PRJNA1266153 and SRA study SRP586839. Searching any of these in the dataset finder brings you back here.

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