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Spatially-patterned and functional kidney assembloids recapitulate progenitor self-assembly and enable high-fidelity in vivo disease modeling [hKPA_invivo_data]

GSE297772 Homo sapiens Expression profiling by high throughput sequencing 5 samples Submitted 2025/08/13 Platform GPL24676
Summary
The paired kidneys are the central organs of homeostasis for our body systems, the sophisticated structure and complex cells composition underpins kidneys’ functions. Here we reported the generation of human kidney progenitor assembloid (KPA) with expandable nephron progenitor cells (NPC) and ureteric bud (UB). These generated hSK showed patterned structure and included nephron, collecting duct and interstitium. More importantly, after transplantation hKPA developed more mature features and vasculature, and transplanted PKD2 hKPA developed abundant cysts, which shared some common features with human ADPKD kidney
Published in
Spatially patterned kidney assembloids recapitulate progenitor self-assembly and enable high-fidelity in vivo disease modeling
Huang B, Medina P, He J et al. · Cell stem cell 2025 · PMID 40967224 · doi:10.1016/j.stem.2025.08.013
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Also filed as BioProject PRJNA1266149 and SRA study SRP586960. Searching any of these in the dataset finder brings you back here.

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