GEO series
Reproducible single cell annotation of programs underlying T cell subsets, activation states, and functions
GSE297814
Homo sapiens
Expression profiling by high throughput sequencing; Other
12 samples
2025/06/01
GPL24676
Summary
CITE-sequencing and TCR-sequencing of sorted activated, unactivated, and mock T cells derived from blood. T cells from five healthy human donors were stimulated with a peptide pool (CEFX, JPT) and anti-CD28/CD49d co-stimulation. Cells were then sorted based on activation (OX40 and PD-L1 for CD4s, CD137 for CD8s) and labeled with corresponding hashing antibodies prior to sequencing. In total, this dataset encompasses 42,370 cells (12,743 AIM-positive, 15,369 AIM-negative, 14,258 Mock).
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Paper (PMID 40903640) ↗
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