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RNA sequence for RMG1 cells with HIF2A knockdown under 1.5% O₂ for 24 hours

GSE297968 Homo sapiens Expression profiling by high throughput sequencing 9 samples Submitted 2025/12/15 Platform GPL24676
Summary
We performed RNA-seq analysis on ovarian clear cell carcinoma (OCCC) cell lines to investigate the transcriptional effects of HIF2A knockdown. Hypoxia-inducible factor 2 alpha (HIF2A) plays a key role in cellular adaptation to low oxygen environments and has been implicated in tumor progression. In this study.A human OCCC cell line, RMG1, was cultured under hypoxic conditions following lentiviral transduction with shHIF2A or a control vector. This dataset provides insights into the downstream gene expression changes and mitochondrial function modulated by HIF2A suppression.
Published in
HIF2A as a prognostic and clinical therapeutic target in ovarian clear cell carcinoma
Jiang M, Yamaguchi K, Hamada K et al. · International journal of cancer 2026 · PMID 41589342 · doi:10.1002/ijc.70341
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Also filed as BioProject PRJNA1267045 and SRA study SRP587414. Searching any of these in the dataset finder brings you back here.

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