GEO series
Host-Directed Antiviral Activity of SB2960 Through Selective Induction and Remodeling of Stress Granules
GSE298032
Homo sapiens
Expression profiling by high throughput sequencing
22 samples
2026/04/28
GPL24676
Summary
The increasing prevalence of emerging infectious diseases highlights the urgent need for broad-spectrum antiviral therapeutics. Here, we report the discovery of SB2960, a small molecule that promotes stress granule (SG) formation and exhibits potent antiviral activity across diverse viral species. Here, we applied genetically-encoded photosentisizer miniSOG induced RNA labeling technique CAP-seq to profile RNA components in SG induced by poly(I:C) and drug SB2960 to investigate how SB2960 modulates the RNAs composition of SGs.
Download
NCBI GEO page ↗
Paper (PMID 41532664) ↗
{# Names what the click gives you. "Open in finder" meant nothing to a
visitor who arrived from a search engine and has never seen the tool. #}
Find more
human RNA-seq datasets →
Similar datasets
- GSE328275 Single-cell RNA sequencing of CD45+ immune cells across primary tumor, sentinel tumor-draining lymph node, and axillary lymph node in treatment-naive triple-negative breast cancer 28 samples
- GSE341753 Cohesin loading at regulatory elements shapes 3D genome folding during erythropoiesis [RNA-Seq] 12 samples
- GSE319969 Spatial and Bulk Transcriptomic Profiling Defines the Molecular Evolution of Cutaneous Squamous Cell Carcinoma and Reveals Stage-Specific Biomarkers of Clinical Relevance [RNA-Seq] 24 samples
- GSE342462 Integrated transcriptomic and bioelectrical profiling of stem-like cellular states in a colorectal cancer using SdFFF and UHF-DEP 12 samples
- GSE313035 METIMMOX: Colorectal Cancer METastasis - Shaping Anti-tumor IMMunity by OXaliplatin 67 samples
- GSE339456 Integrated bulk and spatial transcriptomic analysis identifies progression-associated molecular signatures in biopsy-proven hypertensive nephropathy [RNA-seq] 35 samples
- GSE341139 A conserved HAND2-BMP5-SMAD1/5/9 axis drives hepatic stellate cell activation and extracellular matrix overproduction in multiple fibrotic etiologies 10 samples
- GSE274275 Effect of depletion of NSUN4 on gene expression of NCI-H226 cells [RNA-seq] 6 samples
Share this dataset
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.