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Expression Profiling of Mixed Lineage Leukemia Cells Treated with a Potent Small-Molecule DOT1L Inhibitor

GSE29828 Homo sapiens Expression profiling by array 24 samples Submitted 2011/07/11 Platform GPL570
Summary
Cell lines bearing MLL translocations (MV4-11 and MOLM-13) were treated with a potent, selective inhibitor of the DOT1L histone methyl transferase. Treatment of MLL-rearranged cell lines with the DOT1L inhibitor selectively inhibits H3K79 methylation and blocks expression of leukemogenic genes. Here we provide expression profiling data of cells treated with DOT1L inhibitor or vehicle control.
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Also filed as BioProject PRJNA140999. Searching any of these in the dataset finder brings you back here.

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