Exploring the Transformative Effects of Calorie Restriction on the Lacrimal Gland in Adult Mice
RNA-seq (gene expression) · mouse · 19 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 19 samples: 5 × K B6 6M AL-50W F vs 5 × K B6 6M CR 50W F vs 5 × CJ B6 6M CR 50W F vs 4 × CJ B6 6M AL-50W FGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Exploring the transformative effects of calorie restriction on the lacrimal gland in adult miceGeroScience · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE298317_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1267174 and SRA study SRP587318. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 19 samples.
How we read this: 4 replicated groups read from 19 sample titles; they account for 19 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM9011971 K B6 6M AL-50W F1 K B6 6M AL-50W F
- GSM9011972 K B6 6M AL-50W F2 K B6 6M AL-50W F
- GSM9011973 K B6 6M AL-50W F3 K B6 6M AL-50W F
- GSM9011974 K B6 6M AL-50W F4 K B6 6M AL-50W F
- GSM9011975 K B6 6M AL-50W F5 K B6 6M AL-50W F
- GSM9011976 K B6 6M CR 50W F1 K B6 6M CR 50W F
- GSM9011977 K B6 6M CR 50W F2 K B6 6M CR 50W F
- GSM9011978 K B6 6M CR 50W F3 K B6 6M CR 50W F
- GSM9011979 K B6 6M CR 50W F4 K B6 6M CR 50W F
- GSM9011980 K B6 6M CR 50W F7 K B6 6M CR 50W F
- GSM9011981 CJ B6 6M AL-50W F1 CJ B6 6M AL-50W F
- GSM9011982 CJ B6 6M AL-50W F3 CJ B6 6M AL-50W F
- GSM9011983 CJ B6 6M AL-50W F4 CJ B6 6M AL-50W F
- GSM9011984 CJ B6 6M AL-50W F5 CJ B6 6M AL-50W F
- GSM9011985 CJ B6 6M CR 50W F1 CJ B6 6M CR 50W F
- GSM9011986 CJ B6 6M CR 50W F2 CJ B6 6M CR 50W F
- GSM9011987 CJ B6 6M CR 50W F3 CJ B6 6M CR 50W F
- GSM9011988 CJ B6 6M CR 50W F4 CJ B6 6M CR 50W F
- GSM9011989 CJ B6 6M CR 50W F5 CJ B6 6M CR 50W F
- GSE281747 Exploring the Transformative Effects of Calorie Restriction on the Lacrimal Gland in Adult Mice 8 samples shares transformative, restriction, exploring, lacrimal, calorie, gland, adult
- GSE312237 Spatial transcriptomic profiling identifies lacrimal gland epithelial cell-driven mechanisms underlying autoimmunity in Sjögren’s disease 90 samples shares lacrimal, gland
- GSE286644 Cortical bulk RNA sequencing of APOE-TR mice under calorie restriction and normal diet 69 samples shares restriction, calorie
- GSE263577 Fecal microbiota transfer from autoimmune dry eye disease model mice to conventional mice induces ocular surface inflammation and stereotypic B cell receptor repertoire development in lacrimal gland 48 samples shares lacrimal, gland
- GSE278669 Circadian clocks and periodic anticipated fasting prevent fasting-associated hepatic steatosis in calorie restriction 38 samples shares restriction, calorie
- GSE295860 WNT Mimetic-Induced Lacrimal Gland Regeneration 26 samples shares lacrimal, gland
- GSE333177 A 24-hour light-dark time-series bulk RNA-seq dataset of the mouse lacrimal gland 24 samples shares lacrimal, gland
- GSE320330 Fetal growth restriction leads to prolonged nephrogenesis and persistent developmental gene dysregulation in the adult kidney 18 samples shares restriction, adult
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.