Endothelins positively influences the proliferation vs migration balance of IDH1-mutant glioma cells and promotes proneural to mesenchymal transition [RNAseq-275HUVEC]
RNA-seq (gene expression) · human · 12 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Samples
- 12 samples: 3 × 275_alone vs 3 × 275_cocul vs 3 × HUVEC_alone vs 3 × HUVEC_coculGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- EDNRB-dependent endothelin signaling reduces proliferation and promotes proneural-to-mesenchymal transition in gliomasMolecular oncology · 2026
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE298356_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1269011 and SRA study SRP588376. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 12 samples.
How we read this: 4 replicated groups read from 12 sample titles; they account for 12 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM9012264 275_alone 1 275_alone
- GSM9012265 275_alone 2 275_alone
- GSM9012266 275_alone 3 275_alone
- GSM9012267 275_cocul 1 275_cocul
- GSM9012268 275_cocul 2 275_cocul
- GSM9012269 275_cocul 3 275_cocul
- GSM9012270 HUVEC_alone1 HUVEC_alone
- GSM9012271 HUVEC_alone2 HUVEC_alone
- GSM9012272 HUVEC_alone3 HUVEC_alone
- GSM9012273 HUVEC_cocul1 HUVEC_cocul
- GSM9012274 HUVEC_cocul2 HUVEC_cocul
- GSM9012275 HUVEC_cocul3 HUVEC_cocul
- GSE289535 Mesenchymal-epithelial transition reduces proliferation but increases immune evasion in tumor spheroids 12 samples shares proliferation, mesenchymal, transition
- GSE313416 Transient proliferation by reversible YAP- and mitogen-control of the cyclin D1/p27 ratio 63 samples shares proliferation
- GSE299964 Increased LEF1 protein levels and isoform switching drive cell proliferation in chronic lymphocytic leukemia [RNA-Seq] 50 samples shares proliferation
- GSE265940 Overexpression of extracellular matrix proteins, increased cell death and reduced cell proliferation contribute to the pathophysiology of microphthalmia across in vitro patient-derived models 48 samples shares proliferation
- GSE164893 Post-transcriptional regulation of proliferation and quiescence (mRNAdecay) 48 samples shares proliferation
- GSE296196 Enhancement of activation-induced T cell proliferation by SIRPG in a CD47-independent manner 46 samples shares proliferation
- GSE282456 IRX2 and NPTX1 differential regulation of b-catenin underlies MEK-mediated proliferation in human neuroglial cells 40 samples shares proliferation
- GSE245739 The transcription factor IRF4 impedes human CD8 T-cell function and promotes cells proliferation and PD-1 expression 40 samples shares proliferation
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.