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Human umbilical cord MSCs prime monocytes to recruit and activate eosinophils for enhanced host defence against Klebsiella pneumoniae

GSE298453 Mus musculus Expression profiling by high throughput sequencing 8 samples Submitted 2025/06/03 Platform GPL34290
Summary
The global rise of antibiotic-resistant Klebsiella pneumoniae (KP) underscores an urgent need for novel preventive strategies. Although human mesenchymal stem/stromal cells (hMSCs) exhibit immunomodulatory and antimicrobial properties in preclinical model, their clinical efficacy remains limited. We hypothesized that early prophylactic hUC-MSCs administration in high-risk populations could prime the pulmonary immune microenvironment, conferring protection against KP infection. This study evaluated the efficacy and mechanisms of hUC-MSC-based prophylaxis in a murine KP lung infection model.
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Also filed as BioProject PRJNA1269483 and SRA study SRP588534. Searching any of these in the dataset finder brings you back here.

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