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Potential Targets of Cholesterol Crystal Embolism

GSE298484 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2026/01/01 Platform GPL21103
Summary
Cholesterol crystal (CC) embolism is a severe complication of atherosclerosis, associated with high morbidity and mortality due to its ability to cause acute kidney injury (AKI) and ischemic cortical necrosis. We have established a CC embolism mouse model induced by CC injection. Using this model, we observed significant transcriptomic changes across 17 cell types in the kidneys, with specific upregulation of genes like Cda in the proximal tubular cells, suggesting its potential as an AKI biomarker. Single-cell sequencing revealed the central role of CCL and MIF pathways in CC embolism and identified CCR5 and CD74 as potential therapeutic targets.
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Also filed as BioProject PRJNA1269532 and SRA study SRP588744. Searching any of these in the dataset finder brings you back here.

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