GEO series
Murine oligodendrocyte-derived glioblastoma induced by oncogenic lentivirus in CNP-Cre mice.
GSE298515
Mus musculus
Expression profiling by high throughput sequencing
13 samples
2026/05/29
GPL24247
Summary
Using a CNP-Cre transgenic mouse model, this study investigates the role of differentiated oligodendrocytes as a candidate cell-of-origin for GBM. We show that these cells can give rise to GBM tumors when targeted with Cre-inducible oncogenic lentiviral vectors expressing PDGFB and shP53 or HRasV12 and shp53
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