Human microglia reduce alpha-synuclein aggregation and are neuroprotective in adult mouse brain
RNA-seq (gene expression) · mouse · 24 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 24 samples: 24 samples, each with a distinct title — no replicated groupsGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Human microglia reduce alpha-synuclein aggregation and are neuroprotective in adult mouse brainBrain, behavior, and immunity · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE298706_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1270983 and SRA study SRP589444. Searching any of these in the dataset finder brings you back here.
Any grouping that defines a comparison lives in the sample characteristics, which GEO records separately from the titles.
How we read this: Read from 24 sample titles: 24 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM9021258 52L, Mouse STR LEFT, male, MG-, SAL
- GSM9021259 52R, Mouse STR RIGHT, male, MG+, SAL
- GSM9021260 53L, Mouse STR LEFT, male, MG+, no treatment
- GSM9021261 53R, Mouse STR RIGHT, male, MG-, PFF
- GSM9021262 55L, Mouse STR LEFT, male, MG-, SAL
- GSM9021263 55R, Mouse STR RIGHT, male, MG+, SAL
- GSM9021264 56L, Mouse STR LEFT, female, MG+, no treatment
- GSM9021265 56R, Mouse STR RIGHT, female, MG-, PFF
- GSM9021266 57L, Mouse STR LEFT, female, MG-, PFF
- GSM9021267 57R, Mouse STR RIGHT, female, MG+, PFF
- GSM9021268 58L, Mouse STR LEFT, female, MG-, SAL
- GSM9021269 58R, Mouse STR RIGHT, female, MG+, SAL
- GSM9021270 59L, Mouse STR LEFT, female, MG-, no treatment
- GSM9021271 59R, Mouse STR RIGHT, female, MG+, PFF
- GSM9021272 63L, Mouse STR LEFT, female, MG-, PFF
- GSM9021273 63R, Mouse STR RIGHT, female, MG+, PFF
- GSM9021274 65L, Mouse STR LEFT, female, MG-, no treatment
- GSM9021275 65R, Mouse STR RIGHT, female, MG+, PFF
- GSM9021276 70L, Mouse STR LEFT, female, MG-, no treatment
- GSM9021277 70R, Mouse STR RIGHT, female, MG+, PFF
- GSM9021278 77L, Mouse STR LEFT, male, MG-, no treatment
- GSM9021279 77R, Mouse STR RIGHT, male, MG+, PFF
- GSM9021280 82L, Mouse STR LEFT, female, MG-, no treatment
- GSM9021281 83R, Mouse STR RIGHT, female, sham, PFF
- GSE277025 Inhaled Xenon modulates microglia and ameliorates disease in mouse models of amyloidosis and tauopathy 192 samples shares microglia
- GSE219284 Alzheimer’s disease neuroinflammatory risk genes can be targeted with RNase-H active antisense oligonucleotides in human microglia 24 samples shares microglia
- GSE293117 GPR34 loss-of-function rescues TREM2 metabolic dysfunction and promotes responsive microglial states 56 samples shares microglia
- GSE269121 CD22 modulation regulates neuroinflammation in microglia 20 samples shares microglia
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.