CD22 modulation regulates neuroinflammation in microglia
RNA-seq (gene expression) · mouse · 20 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 20 samples: 14 distinct titles, 2 of them repeatedGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- CD22 modulation alleviates amyloid β-induced neuroinflammationJournal of neuroinflammation · 2025
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE269121_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1120353 and SRA study SRP511932. Searching any of these in the dataset finder brings you back here.
How we read this: Read from 20 sample titles: 14 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8306641 330CTX
- GSM8306642 331CTX
- GSM8306643 334CTX
- GSM8306644 335CTX
- GSM8306645 336CTX
- GSM8306646 338CTX
- GSM8306647 570ctxDay3
- GSM8306648 571ctxDay3
- GSM8306649 575ctxDay3
- GSM8306650 576ctxDay3
- GSM8306651 583ctxDay3
- GSM8306652 584ctxDay3
- GSM8306653 A1
- GSM8306654 A2
- GSM8306655 A3
- GSM8306656 A4
- GSM8306657 B1
- GSM8306658 B2
- GSM8306659 B3
- GSM8306660 B4
- GSE327497 Localized PD-1 CAR T therapy reprograms neuroinflammation. 390 samples shares neuroinflammation
- GSE277025 Inhaled Xenon modulates microglia and ameliorates disease in mouse models of amyloidosis and tauopathy 192 samples shares microglia
- GSE293117 GPR34 loss-of-function rescues TREM2 metabolic dysfunction and promotes responsive microglial states 56 samples shares microglia
- GSE298706 Human microglia reduce alpha-synuclein aggregation and are neuroprotective in adult mouse brain 24 samples shares microglia
- GSE219284 Alzheimer’s disease neuroinflammatory risk genes can be targeted with RNase-H active antisense oligonucleotides in human microglia 24 samples shares microglia
- GSE248813 MED16 negatively regulates erythropoiesis and myelopoiesis through modulation of chromatin accessibility 52 samples shares modulation
- GSE275351 Exploring the Mechanism of SETDB1 in Regulating Neuroinflammation and Anxiety-Depression-like Behaviors [ATAC-seq] 16 samples shares neuroinflammation
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.