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Exosomal SNHG26 derived from drug-resistant tongue squamous cell carcinoma cells inhibits the anticancer effect of NK cells in the microenvironment

GSE298791 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2025/12/31 Platform GPL24676
Summary
Cisplatin resistance is a common occurrence among patients diagnosed with tongue squamous cell carcinoma (TSCC), resulting in a bleak prognosis. The immune microenvironment, specifically the involvement of Natural killer (NK) cells, plays a significant role in the development of drug-resistant tumor cells and subsequently impacts patient prognosis. However, the precise interaction mode and the underlying mechanisms governing this process remain elusive.
Published in
Exosomal SNHG26 mediates immunosuppression by impairing NK cells in tongue cancer
Jiang Q, Xin Y, He F et al. · NPJ precision oncology 2025 · PMID 41390529 · doi:10.1038/s41698-025-01185-0
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Also filed as BioProject PRJNA1271111 and SRA study SRP589331. Searching any of these in the dataset finder brings you back here.

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