NSMF Mitigates Excessive Replication Stress to Facilitate Colorectal Cancer Progression
RNA-seq (gene expression) · human · 26 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Topic
- Colorectal cancerThis series is part of our curated briefing on it.
- Samples
- 26 samples: 16 × 201209SHIN#Groups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- NSMF modulates replication stress to facilitate colorectal cancer progressionNucleic acids research · 2026
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE298852_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1271498 and SRA study SRP589600. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 16 samples.
How we read this: 1 replicated groups read from 26 sample titles; they account for 16 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM9025106 S44Tumor
- GSM9025107 S44NT
- GSM9025108 S14Tumor
- GSM9025109 S14NT
- GSM9025110 S20Tumor
- GSM9025111 S20NT
- GSM9025112 S28Tumor
- GSM9025113 S28NT
- GSM9025114 S26Tumor
- GSM9025115 S26NT
- GSM9025116 201209SHIN#1 201209SHIN#
- GSM9025117 201209SHIN#2 201209SHIN#
- GSM9025118 201209SHIN#3 201209SHIN#
- GSM9025119 201209SHIN#4 201209SHIN#
- GSM9025120 201209SHIN#5 201209SHIN#
- GSM9025121 201209SHIN#6 201209SHIN#
- GSM9025122 201209SHIN#8 201209SHIN#
- GSM9025123 201209SHIN#9 201209SHIN#
- GSM9025124 201209SHIN#10 201209SHIN#
- GSM9025125 201209SHIN#11 201209SHIN#
- GSM9025126 201209SHIN#12 201209SHIN#
- GSM9025127 201209SHIN#13 201209SHIN#
- GSM9025128 201209SHIN#14 201209SHIN#
- GSM9025129 201209SHIN#16 201209SHIN#
- GSM9025130 201209SHIN#19 201209SHIN#
- GSM9025131 201209SHIN#20 201209SHIN#
- GSE250000 Bulk RNA-sequencing of transduced colorectal cancer cell line HCT-116 and breast cancer cell line MCF-7 overexpressing full-lenght p53β or p53β-stop-lost. 4 samples same disease briefing · shares colorectal
- GSE12032 Inherent gene signature of stage II and III colorectal cancer leads in individual recurrence 198 samples same disease briefing · shares colorectal
- GSE109308 Single-cell transcriptomic survey of adenomatous polyposis patients with germline APC mutations 97 samples same disease briefing
- GSE110009 Single cell transcriptome landscape of primary and metastatic tumor in colon cancer 76 samples same disease briefing
- GSE278785 Obesity facilitated colon cancer progression is mediated by increased diacylglycerol o-acyltransferases 1 and 2 (DGAT1/2) levels [RNA-seq] 26 samples shares progression, facilitate
- GSE267491 Inhibition of DEK contributes to the tolerance of replication stress and restores HSC function in Fanconi anemia 91 samples shares replication, stress
- GSE333317 Adrenal-derived factors drive progression of sclerotic prostate cancer in bone 48 samples shares progression
- GSE245733 HNF4G and FOXA1 are context-specific drivers of pancreatic cancer progression [RNA-seq] 29 samples shares progression
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.