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Pharmacological inhibition of sclerostin protects bone from B-cell acute lymphoblastic leukemia-mediated destruction

GSE298870 Mus musculus Expression profiling by high throughput sequencing 8 samples Submitted 2026/05/05 Platform GPL23479
Summary
The cellular components of the BM microenvironment are known to play a role in the development of B-cell acute lymphoblastic leukemia (B-ALL). However, molecular differences between heathy osteoblastic cells (OBCs) and OBCs associated with B-ALL remain unclear. This study utilises bulk RNA-seq to evaluate the molecular signatures between the healthy OBCs and B-ALL-associated OBCs.
Published in
Pharmacological inhibition of sclerostin protects bone from B-cell acute lymphoblastic leukemia-mediated destruction
Kuek V, Oommen J, Ferrari E et al. · HemaSphere 2026 · PMID 42038749 · doi:10.1002/hem3.70355
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Also filed as BioProject PRJNA1271535 and SRA study SRP589623. Searching any of these in the dataset finder brings you back here.

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