Discovery of a Novel DNMT1 Inhibitor with Improved Efficacy in Treating β-Thalassemia [ATAC-seq]
ChIP-seq / ATAC-seq (genome binding and open chromatin) · human · 10 samples
- What it is
- ChIP-seq / ATAC-seq (genome binding and open chromatin)Where proteins bind the genome, or which regions are open and active.
- Organism
- Homo sapiens (human)
- Samples
- 10 samples: 8 distinct titles, 2 of them repeatedGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Discovery of a Novel DNMT1 Inhibitor with Improved Efficacy in Treating β-ThalassemiaAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE298941_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Look for peak files (.bed, .narrowPeak) and signal tracks (.bigWig) among the supplementary files; the raw reads are on ENA.
Also filed as BioProject PRJNA1267699. Searching any of these in the dataset finder brings you back here.
How we read this: Read from 10 sample titles: 8 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM9026285 HUDEP_ATAC_seq_DMSO_Rep1
- GSM9026286 HUDEP_ATAC_seq_DMSO_Rep2
- GSM9026287 HUDEP_ATAC_seq_DMT207_Rep1
- GSM9026288 HUDEP_ATAC_seq_DMT207_Rep2
- GSM9026289 Donor1_CD34_ATAC_seq_DMSO
- GSM9026290 Donor1_CD34_ATAC_seq_DMT207
- GSM9026291 Donor2_CD34_ATAC_seq_DMSO
- GSM9026292 Donor2_CD34_ATAC_seq_DMT207
- GSM9026293 Donor3_CD34_ATAC_seq_DMSO
- GSM9026294 Donor3_CD34_ATAC_seq_DMT207
- GSE270684 The EZH2 and EZH1 inhibitor valemetostat derepresses p16INK4a to induce early endomitotic exit in megakaryocytes [scATAC-Seq] 66 samples shares inhibitor, atac-seq
- GSE281556 Lysosomal sequestration of PARP inhibitors drives heterogeneous accumulation in ovarian cancer to increase efficacy 204 samples shares inhibitor, efficacy
- GSE300177 Catalytic inhibition of KAT6/KAT7 enhances the efficacy and overcomes primary and acquired resistance to Menin inhibitors in MLL leukaemia 194 samples shares inhibitor, efficacy
- GSE281517 Lysosomal sequestration of PARP inhibitors drives heterogeneous accumulation in ovarian cancer to increase efficacy [RNA-seq] 72 samples shares inhibitor, efficacy
- GSE80688 Safety and Efficacy of the JAK Inhibitor Tofacitinib Citrate for Alopecia Areata and Variants 56 samples shares inhibitor, efficacy
- GSE293546 EZH2 inhibitor SHR2554 enhances the anti-tumor efficacy of HDAC inhibitor Chidamide through STAT1 in T-cell lymphoma 34 samples shares inhibitor, efficacy
- GSE301688 Preclinical Evaluation of the Efficacy of a Cyclin-dependent Kinase Inhibitor Ribociclib in Combination with Letrozole Against Patient-Derived Glioblastoma Cells 18 samples shares inhibitor, efficacy
- GSE253723 Reverse translational discovery reveals dysregulation of CD4+ and CD8+ resident memory T, myeloid, and stromal cells in steroid-refractory, checkpoint inhibitor colitis 12 samples shares discovery, inhibitor
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.