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Elucidating the mechanisms underlying KRT19 contributes to NSCLC progression [PC-9 cells_RNA-Seq]

GSE299060 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2026/01/21 Platform GPL34284
Summary
As a member of the acidic type I cytokeratin family, keratin 19 (KRT19) is originally known to form the intermediate filament cytoskeleton and responsible for structural rigidity and multipurpose scaffolds.KRT19 is abnormally expressed in various cancers including hepatocellular carcinoma, breast cancer,serous ovarian cystadenocarcinoma and et.al. KRT19 has been revealed to mediate cell cycle arrest, cancer stem cell reprogramming by interacting with cellular molecules including receptors, adaptors, effectors and kinases. Increasing evidence illustrates the clinical significance of KRT19 in lung cancer, extensive studies are urged to elucidate the role and underlying mechanism of KRT19 in NSCLC progression, we performed RNA-Seq to identify its target genes in PC-9 cell lines.
Published in
Lactylation-driven KRT19 promotes non-small cell lung cancer progression by suppressing cellular senescence
Zhang C, Du Y, Ji Y et al. · Journal of experimental & clinical cancer research : CR 2025 · PMID 41345704 · doi:10.1186/s13046-025-03602-5
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Also filed as BioProject PRJNA1272490 and SRA study SRP590114. Searching any of these in the dataset finder brings you back here.

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