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The mechanism of Sinomenine (SIN) ameliorates the metabolic-associated steatohepatitis (MASH)

GSE299203 Mus musculus Expression profiling by high throughput sequencing 9 samples Submitted 2026/01/01 Platform GPL24247
Summary
The alkaloid, sinomenine (SIN),7,8-didehydro-4-hydroxy-3,7-dimethoxy-17-methylmorphinan-6-one (C19H23NO4), was extracted from the rhizome of the Chinese medicinal plant, Sinomenium acutum (Thunb.) Rehd. et Wils. andS. acutum (Thunb.) Rehd. et Wils. Var. cinereum Rehd. et Wils.SIN has antiinflammatory, analgesic,immunosuppressive,antihypertensive, and antiarrhythmic effects. It has been used totreat rheumatoid diseases in humans.Our laboratory has shown that SIN can attenuate the inflammation in dextran sulfate-induced colitis, but it is unclear in metabolic-associated steatohepatitis (MASH).
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Also filed as BioProject PRJNA1273057 and SRA study SRP590393. Searching any of these in the dataset finder brings you back here.

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