PUMA-induced apoptosis in telomere biology disorders
RNA-seq (gene expression) · mouse · 15 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 15 samples: 4 × Puma vs 4 × TERC vs 4 × TercPuma vs 3 × WTGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- PUMA-induced apoptosis drives bone marrow failure and genomic instability in telomerase-deficient miceCell death and differentiation · 2026
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE299229_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1273111 and SRA study SRP590423. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 15 samples.
How we read this: 4 replicated groups read from 15 sample titles; they account for 15 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM9035636 WT rep1 WT
- GSM9035637 WT rep2 WT
- GSM9035638 WT rep3 WT
- GSM9035639 Puma rep1 Puma
- GSM9035640 Puma rep2 Puma
- GSM9035641 Puma rep3 Puma
- GSM9035642 Puma rep4 Puma
- GSM9035643 TERC rep1 TERC
- GSM9035644 TERC rep2 TERC
- GSM9035645 TERC rep3 TERC
- GSM9035646 TERC rep4 TERC
- GSM9035647 TercPuma rep1 TercPuma
- GSM9035648 TercPuma rep2 TercPuma
- GSM9035649 TercPuma rep3 TercPuma
- GSM9035650 TercPuma rep4 TercPuma
- GSE267633 Differential Effects of Prenatal Alcohol Exposure in Mice on Brain Growth and Gene Expression Reveals Early Effects on Cell Cycle and Apoptosis and Delayed Effects on Metabolism in Affected Offspring 151 samples shares apoptosis
- GSE282889 Reduction of intestinal RIPK1 ameliorates HFD-induced metabolic disorders in female mice 74 samples shares disorders
- GSE248222 Impact of Maternal Immune Activation and Sex on Placental and Fetal Brain Cytokine and Gene Expression Profiles in a Preclinical Model of Neurodevelopmental Disorders 64 samples shares disorders
- GSE272272 Changes in the astrocyte translatome induced by developmental ethanol mediate dysregulation of neuronal development: role of the extracellular matrix and relevance to Fetal Alcohol Spectrum Disorders 48 samples shares disorders
- GSE281823 Transcriptional profiling of striatum from the Q140 mouse model of Huntington's disease, from A rare genetic variant confers resistance to neurodegeneration across multiple neurological disorders by augmenting selective autophagy 40 samples shares disorders
- GSE196482 Integrated analysis of early transcriptomic and proteomic alterations in mouse models of ALS/FTD identify early metabolic adaptions with similarities to mitochondrial dysfunction disorders 40 samples shares disorders
- GSE252120 Oxidative stress induced telomere instability/damage drives T cell dysfunction in cancer 32 samples shares telomere
- GSE255938 Effects of prenatal maternal immune activation and exposure to circadian disruption during adolescence: exploring the two-hit model of neurodevelopmental disorders 32 samples shares disorders
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.