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RNA-seq Analysis Reveals the Anti-inflammatory Role of hnRNPF in Diabetic kidney disease

GSE299230 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2025/06/07 Platform GPL20795
Summary
In this study, a hyperosmotic environment was simulated using 30 mM mannitol. Human renal proximal tubular epithelial (HK-2) cells were transfected to overexpress hnRNP-F, with empty vector-transfected cells serving as the negative control (NC). RNA sequencing (RNA-seq) was performed to profile transcriptomic changes, enabling comprehensive analysis of hnRNP-F overexpression-induced alterations in differentially expressed genes (DEGs) and alternative splicing events (ASEs) under hyperosmotic stress. These data were integrated with our previously acquired dataset profiling hnRNP-F-driven DEG and ASE regulation in HK-2 cells under hyperglycemic conditions.
Published in
Integrative RNA-seq and CLIP-seq analysis reveals hnRNP-F regulation of TNFα/NFκB signaling in high-glucose conditions
Wang L, Li H, Guo X et al. · Frontiers in physiology 2025 · PMID 40995516 · doi:10.3389/fphys.2025.1475441
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Also filed as BioProject PRJNA1273117 and SRA study SRP590424. Searching any of these in the dataset finder brings you back here.

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