GEO series
Multiomics analyses reveal the role of Glis3 in polycystic kidney disease
GSE299238
Mus musculus
Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing
24 samples
2025/07/30
GPL24247
Summary
We performed unbiased transcriptional profiling and chromatin accessibility analyses on adult kidney tissues from allelic series of Pkd1 and Glis3 inactivation mouse models. Glis3 is a modifer of cyst progression whose inactivation exacerbates polycystic kidney disease. Through the integration of multiomic datasets, we generated hypotheses to explain the worsening phenotype observed in Pkd1 and Glis3 double mutants.
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Paper (PMID 40661540) ↗
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