GEO series
Bulk RNASeq S64F MAFA male islets
GSE299343
Mus musculus
Expression profiling by high throughput sequencing
22 samples
2025/12/01
GPL24247
Summary
Mice harboring the S64F mutation in the endogenous MafA gene ("Het") on a mixed genetic background (SJL x C57/Bl6J) show impaired glucose tolerance then overt diabetes by 5 weeks of age. Moreover, when backcrossed to the C57/Bl6J background, mutant Het mice are euglycemic similar to their wild type littermates, suggesting compensation which can prevent diabetes.
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