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Erianin induces apoptosis and pyroptosis via MAPK/ERK and PI3K/Akt pathways and synergizes with anlotinib in anaplastic thyroid carcinoma

GSE299493 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2025/09/24 Platform GPL23227
Summary
Anaplastic thyroid carcinoma (ATC) is an aggressive thyroid malignancy characterized by rapid progression, resistance to conventional therapies, and poor patient prognosis. There is an urgent need for innovative therapeutic strategies. Erianin, a natural compound derived from Dendrobium, has demonstrated significant anti-tumor effects in various cancers, yet its role in ATC remains unexplored.In this study, we confirmed the significant anticancer effects of erianin on ATC through both in vitro and in vivo models, including the induction of apoptosis and GSDME-dependent pyroptosis in ATC cells.
Published in
Erianin induces apoptosis and pyroptosis via MAPK/ERK and PI3K/Akt pathways and synergizes with anlotinib in anaplastic thyroid carcinoma
Zhang Q, Qiu M, Liu J et al. · Frontiers in pharmacology 2025 · PMID 40978473 · doi:10.3389/fphar.2025.1596873
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Also filed as BioProject PRJNA1274824 and SRA study SRP591514. Searching any of these in the dataset finder brings you back here.

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